How to prescribe TRYNGOLZA
e-Prescribe TRYNGOLZA through your electronic health record (EHR) system to an in-network pharmacy*
Download the TRYNGOLZA Start Form or use the Tear Pad from your Account Specialist, then fax the completed form to an in-network pharmacy*
*See below for a full list of pharmacies in the TRYNGOLZA network.
TRYNGOLZA is available through a select pharmacy network
Use of a specific pharmacy may be required by some insurance plans or pharmacy benefit managers (PBMs), so it is important to confirm with the patient’s plan prior to sending the prescription.
| Pharmacy | Phone number | Fax number | Common payer/ PBM affiliations |
|---|---|---|---|
| Accredo | 1-844- 516-3319 | 1-888- 302-1028 | • Cigna
|
| BlinkRx | 1-844- 926-2480 | 1-866- 585-4631 | • Independent health plans |
| CVS Specialty | 1-800- 237-2767 | 1-800- 323-2445 | • Aetna • CVS Health |
| Optum Specialty Pharmacy | 1-855- 427-4682 | 1-877- 342-4596 | • Optum Rx • United HealthcareUnited-Healthcare |
Reminder: Encourage your patient to save their pharmacy’s number in their phone to help them recognize and answer the calls for setting up TRYNGOLZA delivery.
Our pharmacy partners are here to support your patients and your office
BlinkRx is the digital pharmacy in our network. It is a digital platform for prescription fulfillment that can integrate into your office workflow, accept all insurance plan types, and triage the prescription to another plan-mandated pharmacy in our network, if needed.
Accredo, CVS Specialty, and Optum Specialty Pharmacy are the specialty pharmacies (SPs) in our network. Sending the prescription to one of these SPs may be your preferred option if the plan requires use of a specific SP or if your patient prefers an SP.
CuraScript SD by Evernorth is the specialty distributor for TRYNGOLZA.
Navigating access to TRYNGOLZA for your patients
The following supplementary clinical documentation is recommended to submit to insurance plans to confirm medical necessity:
- Recent blood work showing your patient's fasting triglyceride levels
- History of acute pancreatitis events
- Prior and/or current therapies used to manage high triglycerides
- Additional materials that can be helpful†
- TRYNGOLZA Prescribing Information
- FDA Approval Letter
- Letter of Medical Necessity‡
- AHA/ACC multi-society guideline on the management of dyslipidemia (2026), which includes sHTG treatment guidelines
For questions regarding TRYNGOLZA coverage, please reach out to your Ionis CAS.
†These materials are especially important to include with your request during the pre-policy period.
‡Find a Sample Letter of Medical Necessity on our "Resources" page here.
ACC=American College of Cardiology; AHA=American Heart Association; sHTG=severe hypertriglyceridemia.
Support to help your patients take control
Ionis Every Step™ is a support program designed to help your patients navigate treatment with TRYNGOLZA.
Ionis Every Step offers a broad range of support to help your patients at each step of the TRYNGOLZA treatment journey.
Our pharmacy partners can provide your patients and your office with comprehensive access support.* We can help with:
- Managing prior authorizations
- Navigating coverage denials
- Preparing for reauthorization
*Insurance approval is not guaranteed. Ionis Every Step offers financial assistance programs for patients who are uninsured or denied coverage for their Ionis medication.
Ionis Every Step and our pharmacy partners will connect eligible patients with coverage and affordability options*
- Your eligible, commercially insured patients may pay as little as $0 per fill of TRYNGOLZA with the Ionis Every Step Copay Program†
- If your patient's insurance doesn't cover their prescription or if they don't have insurance, they may be eligible to get TRYNGOLZA at no cost through the Ionis Every Step Patient Assistance Program (PAP)*
- Continued eligibility depends on additional reviews of insurance and financial information, including an annual PAP reapplication process
*Subject to program terms, conditions, and limits. Ionis Every Step consent is required for participation in all Ionis Every Step coverage and affordability programs.
†Eligibility restrictions: This program is not available to individuals who use any state or federal government-funded health care program to cover a portion of medication costs, such as Medicare, Medicaid, TRICARE, Department of Defense, or Veterans Administration, or any other state or federal government-funded health care program. Ionis Every Step consent is required for participation in all Ionis Every Step coverage and affordability programs.
Ionis Every Step stays connected with your patient’s pharmacy to provide ongoing support throughout their treatment. We will:
- Provide injection training to help patients confidently administer TRYNGOLZA
- Regularly check in with patients and help them take an active role in managing their health
- Connect patients with an extra level of support if they need more help using TRYNGOLZA
Ionis Every Step offers educational resources that patients can explore at their own pace. Digital resources are available at their fingertips, with information on:
- How to administer TRYNGOLZA
- Nutrition tips and tools to help them take control of their health
- Understanding and reaching their treatment goals
Your patients can choose 1 of the following options to enroll in Ionis Every Step:
For additional support signing up or if patients have any questions, they can call the Ionis Every Step TRYNGOLZA Support Center at 1-844-789-8744 (select option 2), 8 AM to 8 PM ET.
Frequently asked questions about getting your patients started on TRYNGOLZA
Yes, you can e-Prescribe TRYNGOLZA through your electronic health record system to an in-network pharmacy. Or you can download the TRYNGOLZA Start Form and fax the completed form to an in-network pharmacy.
Use of a specific pharmacy may be required by some insurance plans, so it is important to confirm with the patient’s plan prior to sending the prescription.
TRYNGOLZA is typically covered under the pharmacy benefit, and patients may need to meet specific coverage criteria to receive approval from their insurance plan.
Your patient's pharmacy will send you an electronic prior authorization (PA) request to complete—you will need to fill out the PA form and confirm that the patient meets all clinical coverage criteria before submitting the request. The pharmacy will send you plan-specific forms and can direct you to resources to support the submission process.
Proactively submitting relevant clinical documentation can help avoid unnecessary delays in the insurance approval process. These materials may include:
- Recent blood work showing your patient’s fasting triglyceride levels
- History of acute pancreatitis events
- Prior and/or current therapies used to manage high triglycerides
- Additional materials that can be helpful*
- TRYNGOLZA Prescribing Information
- FDA Approval Letter
- Letter of Medical Necessity†
- AHA/ACC multi-society guideline on the management of dyslipidemia (2026), which includes sHTG treatment guidelines
These materials are submitted through an exception or prior authorization request, which the pharmacy will initiate and send to your office so you can fill out the appropriate form.
The pharmacy will send you plan-specific forms and can direct you to resources to support the submission process. You will need to determine what documentation and information is required by the insurance plan to show medical necessity for TRYNGOLZA.
*These materials are especially important to include with your request during the pre-policy period.
†Find a Sample Letter of Medical Necessity on our "Resources" page here.
ACC=American College of Cardiology; AHA=American Heart Association; sHTG=severe hypertriglyceridemia.
After sending the TRYNGOLZA prescription using your preferred prescribing method (electronically or via fax), the patient's pharmacy will send your office an electronic prior authorization (PA) request through CoverMyMeds or via fax.
The pharmacy will send you plan-specific forms and can direct you to resources to support the submission process. Although the pharmacy will initiate this request, it is important you complete the form, verify that your patient meets the plan-specific coverage criteria, and submit the request through CoverMyMeds in a timely manner.
After receiving a denial, you can appeal and ask the insurance plan to reconsider their decision. Get started with the steps below:
- Review the communication from the plan to understand the reason(s) for denial, and send the denial letter to the pharmacy
- Scheduling a peer-to-peer review may be helpful if the denial occurs during the pre-policy period, and is typically conducted before filing a formal appeal
- Use this scheduled phone conversation to discuss your clinical rationale for why the denial should be overturned
- If this does not result in denial being overturned, the next step is sending a formal Letter of Appeal
- Draft a Letter of Appeal to provide additional rationale for your treatment decision and include relevant documentation
Download a Sample Letter of Appeal or explore additional resources that can provide support if you encounter denials for TRYNGOLZA.
The pharmacy can assist your office after a coverage rejection or denial. Reach out to them for support, or if you have additional questions, call the TRYNGOLZA Support Center at 1-844-798-8744, Monday to Friday, 8 AM to 8 PM ET.
An in-network pharmacy will call your patient directly to set up delivery. TRYNGOLZA will not be shipped until your patient speaks with the pharmacy about potential costs and confirms delivery details. Encourage your patient to save their pharmacy’s number in their phone so they recognize their calls.